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Natural Anti-viral Combination for Phrophylaxis & Treatment of COVID-19

QUERCETIN for the Treatment of COVID-19. Quercetin is a multipotent bioflavonoid with great potential for the prevention and treatment of disease. Quercetin is said to be one of the most widely used bioflavonoids for the treatment of metabolic and inflammatory disorders. Quercetin glycosides are metabolized, absorbed, and circulated as types of conjugates in the blood. Thereafter, quercetin-3-O-β-D-glucuronide (Q3GA), a major metabolite of quercetin, is distributed throughout the body where it may exert beneficial functions in target tissues. 

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Quercetin is a Flavonol a subtype of potent substances called flavonoids that naturally occur in plants and offer a variety of beneficial health benefits to humans. In particular, quercetin is found in rinds, young shoots, and barks of plants, and is one of the most abundant flavonoids in our diets.

Foods that commonly contain quercetin include onions, apples, grapes, berries, broccoli, citrus fruits, cherries, green tea, coffee, red wine, and capers. It is available as a dietary supplement in powder and capsule form. Typical dosages range from 500-1000 mg per day.

Quercetin as a supplement is generally well-tolerated, and side effects are uncommon at doses of 500-1000mg/day. The most common side effects are stomach upset, headache, and tingling of the arms and legs.

Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. It was shown that quercetin has the ability to chelate zinc ions and act as zinc ionophore. Therefore, quercetin could have antiviral activity against many RNA viruses. It has unique biological properties that may improve the reduction of infection risk.

Through several screening studies of natural compounds identified quercetin as a promising candidate targeting the SARS-CoV-2 through two mechanisms which are as follows:
1. Prevention of virus from entering the host cell through inhibition of ACE-2. The interaction of Angiotensin Converting Enzyme-2 (ACE-2) with viral spike protein is a critical initial step for the entry of virus to the human host cell.
2. Inhibition of cysteine proteases, 3CLpro & PLpro. The viral main protease Mpro or 3-chymotrypsin like proteases (3CLpro) and papain like protease (PLpro) controls the activities of the coronavirus replication complex.